Table 1.

Monogenic causes of SSNS.

Gene	Locus	Type of mutation	Protein localization	Associated with SRNS	Extra renal manifestations	References
EMP2	16p13	Missense, Truncating	Podocyte	Y	No	(60)
EXT1	8q23	Missense	Glomerular basement membrane	N	Multiple exostoses	(61)
FOXP3	Xp11	Missense	Immune cells	Y	Immunodeficiency, Polyendocrinopathy, Enteropathy	(62)
KANK1	9p24	Missense	Podocyte	Y	No	(63)
KANK2	19p13	Missense	Podocyte	Y	No	(63)
NPHS1	19q12	Missense	Podocyte and slit diaphragm	Y	No	(64), (65)
PLCE1	10q23	Truncating	Podocyte and slit diaphragm	Y	No	(66)
MAGI2	7q21	Truncating	Podocyte	Y	Neurologic impairment	(67)
TNS2	12q13	Missense	Podocyte	Y	Asthma, Hypertension, Short Stature	(67)
DLC1	8p22	Missense, Truncating	Podocyte	Y	Hypertension, Seizures, Visual Disturbance	(67)
CDK20	9q22	Missense	Podocyte	N	No	(67)
ITSN1	21q22	Missense	Podocyte	Y	No	(67)
ITSN2	2p23	Missense	Podocyte	N	No	(67)