Table 4.
Candidate gene polymorphism studies in childhood SSNS.
| Gene | Association | Total NS cohort (SSNS) | Ethnicity | References |
|---|---|---|---|---|
| ABCB1 (MDR1) | Steroid response | 120 (80) | Egyptian | (95) |
| Steroid response | 170 (69) | Korean | (96) | |
| Steroid response | 150 (50) | Egyptian | (97) | |
| NS/Steroid response | 63 | Tunisian | (98) | |
| Steroid response | 74 (58) | Chinese | (99) | |
| Steroid response | 216 (137) | North Indian | (100) | |
| Steroid response | 138 (92) | Egyptian | (101) | |
| Age/Steroid response | 46 (33) | Slovakian | (102) | |
| GR (NR3C1) | Steroid response | 154 | Chinese | (103) |
| TNFα | Steroid response | 150 (100) | Egyptian | (104) |
| IL-4 | Frequent relapse | 55 (55) | Chinese | (105) |
| ACE | NS/Frequent relapse | 227 (144) | Turkish | (106) |
| Steroid response | 125 (90) | Indian | (107) | |
| IL12B | Steroid dependence | 79 (79) | German | (108) |