Table 4.
Univariate and multivariate cox regression analyses of clinicopathological parameters and TIL in validation cohort.
| Clinicopathological parameters | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Gender (male/female) | 0.716 | 0.486−1.056 | 0.092 | |||
| Age (≤ 50/>50) | 1.151 | 0.616−2.152 | 0.660 | |||
| Tumor Size (≤ 5/>5 cm) | 1.472 | 0.995−2.179 | 0.053 | |||
| Histological Grade (high/low) | 2.522 | 1.663−3.826 | <0.001 | 1.446 | 0.850−2.460 | 0.174 |
| LN metastatic (+/−) | 4.677 | 2.697−8.109 | <0.001 | |||
| Nerve invasion (+/−) | 2.504 | 1.632−3.841 | <0.001 | 1.366 | 0.828−2.252 | 0.222 |
| Tumor Thrombus (+/−) | 2.867 | 1.824−4.508 | <0.001 | 1.025 | 0.603−1.743 | 0.927 |
| pTN (I-III) | ||||||
| I | Reference | Reference | ||||
| II | 4.809 | 1.851−12.50 | <0.001 | 3.076 | 1.103−8.573 | 0.032 |
| III | 15.21 | 6.113−37.84 | <0.001 | 7.458 | 2.583−21.54 | <0.001 |
| WHO SUBTYPES | ||||||
| Tubular | Reference | Reference | ||||
| Mucinous | 2.105 | 1.118−3.965 | 0.021 | 0.792 | 0.398−1.573 | 0.505 |
| Papillary | 2.187 | 0.990−4.835 | 0.053 | 2.464 | 0.967−6.279 | 0.059 |
| Poorly cohesive | 2.562 | 1.520−4.318 | <0.001 | 1.023 | 0.565−1.851 | 0.940 |
| Undifferentiated | 2.051 | 1.132−3.717 | 0.018 | 1.042 | 0.539−2.016 | 0.902 |
| Gastrectomy (Palliative/Radical) | 6.421 | 3.695−11.16 | <0.001 | 3.583 | 1.916−6.701 | <0.001 |
| Chemotherapy (+/−) | 1.426 | 0.967−2.104 | 0.073 | |||
| TIL (high/low) | 0.326 | 0.212−0.502 | <0.001 | 0.500 | 0.313−0.797 | 0.004 |
Values in bold signify P < 0.05.