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. 2019 Jan 29;10:83. doi: 10.3389/fimmu.2019.00083

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Copyright © 2019 Graver, Boots, Haacke, Diepstra, Brouwer and Sandovici.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ATLOs in the aorta of LV-GCA and atherosclerosis patients. (A) Representative images of consecutive sections of aorta tissue showing in brown B-cells (CD20), T-cells (CD3), FDC (CD21), GCs (bcl6), and HEV (PNAd). The upper panel shows an ATLO without GC (bcl6–) and the lower panel an ATLO with GC (bcl6+). (B) Relative frequency of patients with ATLOs (ATLO+) and without ATLOs (ATLO–) in the aorta for both LV-GCA and atherosclerosis patients. (C) Number of ATLOs per 20 mm of aortic tissue for both LV-GCA and atherosclerosis patients. (D) Lack of association between atherosclerosis (number of plaques) and the number of ATLOs for LV-GCA patients. Fischer's exact test was used in (B), Mann-whitney U-test in (C) and Spearmans r was used for (D). ^*P < 0.05.