Figure 2.

Cordycepin increases energy expenditure and adaptive thermogenesis. Energy expenditure was evaluated by measurement of oxygen consumption (VO₂) (A) and carbon dioxide release (VCO₂) (C) over a 24 h period after 4 weeks of cordycepin treatment. Energy expenditure was expressed as kcal/day per animal (E). The adjacent bar graphs represent the average for each group (B for A, D for C and F for E). (G) Body temperature during cold exposure was recorded in 30 min intervals. After food deprivation, rectal temperatures were measured at the indicated time points for mice placed in a cold room. (H) Average decrease of body temperature. (I) The skin temperature photos taken by infrared camera. (J) The skin temperature around the shoulder (BAT) and inguina (iWAT) measured by infrared camera. Data are displayed as mean±SEM, n=7. Significant differences compared with vehicle controls are indicated by ^*P < 0.05, ^**P < 0.01 and ^**P < 0.001 (assessed by Student׳s t-test). N.S.: nonsignficance. Cpn: cordycepin.