Table 1.

Brief summary of the involvement of connexins and pannexins in demyelinating diseases.

Disease	Cell type	Connexin or Pannexin	References
Charcot-Marie-Tooth (CMT)	ND	Cx32	Fairweather et al. (1994), Nelis et al. (1996)
	Oligodendrocytes	Cx32	Olympiou et al. (2016)
	Schwann cells and oligodendrocytes	Cx32	Scherer et al. (1998), Kleopa et al. (2002)
	Oligodendrocytes	Cx32 and Cx45	Kunzelmann et al. (1997), Kleopa et al. (2010)
Myelination defects and neuronal hyperexcitability	Schwann cells	Cx32	Sutor et al. (2000)
Pelizaeus-Merzbacher-like (hypomyelinating leukodystrophy 2) and hereditary spastic paraplegia	Oligodendrocytes	Cx47	Osaka et al. (2010), Sargiannidou et al. (2010), Tress et al. (2011), Cotrina and Nedergaard (2012), Zlomuzica et al. (2012)
Oligodendrocyte identity and survival	Oligodendrocytes	Cx47	Schlierf et al. (2006), Pozniak et al. (2010), Takada et al. (2010), Suzuki et al. (2017)
Leukodystrophy	Oligodendrocytes Astrocytes	Cx47	Fasciani et al. (2018)
Multiple sclerosis	Oligodendrocytes	Cx32 and Cx47	Markoullis et al. (2012, 2014)
Experimental autoimmune encephalomyelitis (model of multiple sclerosis)	Oligodendrocytes	Cx32 and Cx47	Constantinescu et al. (2011)
Hypomyelinated leukodystrophy	Oligodendrocytes	Cx32 and Cx47	Wasseff and Scherer (2015)
Demyelination	Oligodendrocytes	Panx1	Hainz et al. (2017)

*This table was intended to show several examples and does not correspond to a compilation of all published evidence. ND, not determined.