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. 2019 Feb 4;9:66. doi: 10.1038/s41398-019-0380-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Methods are the same as in the previous study. EEG was recorded while 14-month-old infants watched dynamic videos. At 36 months, a clinical assessment and measurements of dimensional ASD traits were performed. Developmental abilities were assessed at both visits. EEG data were cleaned, preprocessed, and cut into 1-s epochs. After Fast Fourier Transformations, the debiased Weighted Phase Lag Index (dbWPLI) was calculated. Connectivity matrices contain connectivity values for each possible connection pair. These were averaged across the frequencies for the 7–8 Hz band. We used the connectivity matrices of each infant to assess network differences between groups with the Network Based Statistics program. Global dbWPLI was calculated by averaging values below the diagonal of the connectivity matrices. These values were used to assess differences on group level. Finally, average connectivity in selected connections only (here displayed in yellow) was used to investigate the correlations between functional connectivity and dimensional traits. MSEL Mullen Scales for Early Learning, ADI-R Autism Diagnostic Interview–Revised, ADOS-2 Autism Diagnostic Observational Schedule–2, NBS Network Based Statistics, dbWPLI debiased Weighted Phase Lag Index