Fig. 3.

Crystal structure of the TERB2_MBM–MAJIN_NTD complex. a Ribbon diagrams of two orthogonal views of the TERB2_MBM–MAJIN_NTD complex. TERB2_MBM is colored in magenta and MAJIN_NTD in blue. b Electrostatic surface potential of TERB2_MBM-binding site of MAJIN_NTD. Positive potential, blue; negative potential, red. c, d Detailed interactions at the TERB2_MBM–MAJIN_NTD interface. The color scheme is the same as in a. Residues important for the interaction are shown in stick models. Salt bridges and hydrogen-bonding interactions are shown as magenta dashed lines. e Ribbon diagram shows the potential heterotetramer mode of the TERB2_MBM–MAJIN_NTD complex revealed in the crystal structure. f Structural model of the connection between telomeres and the NE through the TRF1–TERB1–TERB2–MAJIN interaction network