Table 3.

Reduced BOLD signaling compared to baseline within the hypothesized ROIs of the default mode network in each condition and the “touch pleasantness weighted” contrast. Results are presented FWE-corrected.

Condition	DMN node	Cluster size	T value	MNI coordinates x y z			FWE corrected p value: peak level
Interpersonal touch, C-tactile targeted	mPFC
	I	38	6.29	−11	−10	42	<0.001
	PCC/Rsp
	I	5	5.50	−5	−20	50	<0.001
	IPL
	No suprathreshold activation * activated with a more liberal threshold
	LTC
	I	9	5.94	55	−4	−18	<0.001
	II	7	6.05	57	−8	−6	<0.001
	HF/PH
	I	49	6.65	25	−38	−10	<0.001
	II	8	5.68	29	−26	−22	<0.001
Interpersonal touch, Non-c-tactile-targeted	mPFC
	I	6	5.32	−9	−8	42	<0.001
	PCC/Rsp
	No suprathreshold activation * activated with a more liberal threshold
	IPL
	I	5	5.32	45	−74	8	<0.001
	LTC
	No suprathreshold activation * activated with a more liberal threshold
	HF/PH
	I	30	6.01	29	−22	−22	<0.001
	II	5	5.73	23	−34	−14	<0.001
Impersonal touch, C-tactile-targeted	mPFC
	No suprathreshold activation * activated with a more liberal threshold
	PCC/Rsp
	I	30	6.16	15	−62	26	<0.001
	II	15	5.10	−3	−42	44	<0.001
	IPL
	No suprathreshold activation * activated with a more liberal threshold
	LTC
	No suprathreshold activation * activated with a more liberal threshold
	HF/PH
	I	12	5.27	29	−28	−8	<0.001
	II	8	5.15	29	−30	−18	<0.001
Impersonal touch, Non-C-tactile-targeted	mPFC
	No suprathreshold activation * activated with a more liberal threshold
	PCC/Rsp
	No suprathreshold activation * activated with a more liberal threshold
	IPL
	No suprathreshold activation * activated with a more liberal threshold
	LTC
	No suprathreshold activation * activated with a more liberal threshold
	HF/PH
	No suprathreshold activation * activated with a more liberal threshold
Touch pleasantness weighted	mPFC
	I	174	7.86	−9	−8	42	<0.001
	II	43	6.00	3	4	40	<0.001
	PCC/Rsp
	I	93	6.82	−3	−20	50	<0.001
	II	78	6.26	11	−60	22	<0.001
	III	58	6.50	−9	−46	6	<0.001
	IV	13	6.17	15	−34	44	<0.001
	V	2	5.78	25	−78	18	<0.001
	IPL
	I	10	6.29	45	−74	8	<0.001
	II	10	5.66	−41	−76	24
	III	5	5.81	43	−78	8	<0.001
	LTC
	I	21	6.93	53	−6	−18	<0.001
	HF/PH
	I	142	7.09	29	−30	−18	<0.001
	II	56	6.27	29	−30	−6	<0.001

DMN nodes were a priori-defined. In result, we identified reduced BOLD response within the DMN in each of the four touch conditions and the “touch pleasantness weighted” contrast (please note: for a sufficient deactivation of DMN in the impersonal, non-c-tactile targeted condition, a more liberal threshold of p < 0.001, uncorrected, needs to be applied). Labels I to VI are different clusters within the same anatomical ROI. Direct comparison between the four touch conditions revealed no significant effect.

mPFC = medial prefrontal cortex; PCC = posterior cingulate cortex; IPL = inferior parietal lobule; LTC = lateral temporal cortex; HF/PH = hippocampal and parahippocampal formation.