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. 2019 Feb 4;9:1225. doi: 10.1038/s41598-018-37883-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of the immunogen, ovalbumin, in YUMM1.1 tumor cells promotes T cell-mediated tumor control. (a) Tumor growth and survival of 3 × 10⁵ YUMM1.1 cells in C57BL/6 mice or NSG mice, with survival measured as time for tumors to reach >1200 mm³. ns – not significant, log-rank (Mantel-Cox) test, n = 5–8. (b) YUMM1.1-OVA sorted by FACS into low and high GFP-expressing populations; YOVAL1.1 and YOVAH1.1, respectively. (c) Killing by OT-I T cells co-cultured for 4 hours at indicated ratios with 51Cr-labelled target cells pre-stimulated +/− IFNγ. One way ANOVA, Tukey’s multiple comparisons test, n = 3. (d) YOVAL1.1 tumor growth and survival in C57BL/6 mice or NSG mice with survival measured as time for tumors to reach >1200 mm³, log-rank (Mantel-Cox) test, n = 3–5. (e) Growth of YOVAL1.1 in NSG or Rag1^−/− mice, n = 3. (f) YOVAL1.1 tumor growth and survival following transfer of activated OT-I T cells or PBS. YV1.1 – YUMM1.1 transduced with empty vector. All error bars show ±SEM. **p < 0.01, ***p < 0.001.