Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 4;9:1381. doi: 10.1038/s41598-018-37860-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Pulmonary TB patients display a unique profile of circulating biochemical parameters of inflammation. (a) Upper panel: A hierarchical clustering analysis (Ward’s method) was employed to illustrate the overall profile of inflammatory parameters in pulmonary TB patients or healthy controls. Each column represents one patient. Fold differences (TB vs. healthy controls) were calculated and statistically significant differences are highlighted in purple. Lower panel: Histogram for individual values of hemoglobin (Hb). Distributions of Hb were compared between TB patients and healthy controls using the Mann-Whitney U test. ***p < 0.0001. (b) A principal component analysis (PCA) model was employed to test whether combination of the markers evaluated could cluster TB patients separately from controls. A vector analysis was utilized to illustrate the influence of each biochemical parameter in the distribution of the data of the PCA model. Markers in red indicate those with the highest fold-difference values between TB and healthy controls. Abbreviations: ALP, alkaline phosphatase; ALT, alanine transaminase; AST, aspartate aminotransferase; Gamma-GT, gamma-glutamyl transferase; HDL, high-density lipoprotein; LDH, lactate dehydrogenase; LDL, low-density lipoprotein; VLDL, very-low-density lipoprotein.