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. 2019 Feb 4;9:1161. doi: 10.1038/s41598-018-37894-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Involvement of PU.1 in the expression of the human CCL22 gene. (a) mRNA levels of CCL22 and SPI1 in SPI1 siRNA (siSPI1) or control siRNA (siNega) introduced THP-1 cells. (b) Alignment of nucleotide sequences of human and mouse CCL22 genes. (c) ChIP assay was performed using either control IgG (gIgG) or anti-PU.1 Ab (α-PU.1) in THP-1 cells. The amounts of immunoprecipitated chromatin were determined by quantitative PCR targeting the −153/−76 (including cis-elements) or −2106/−2046 (cis-control) of the CCL22 promoter. Results are shown as means + S.D.s of three independent experiments.