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. 2019 Feb 4;9:1197. doi: 10.1038/s41598-018-37667-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The pertinent features of the phosphocholine pathways. The CDP-DAG phosphocholine pathway shows the involvement of genes implicated in the eQTL–based phosphocholine subnetwork (Blue font) - CHO1, OPI3 and ITR1 (transport of external inositol). PA inhibits the Opi1 repressor translocation to the nucleus. Low levels of PA result in translocation of Opi1 to the nucleus and the association and repression of the Ino2/Ino4 heterodimeric transcription factor. Low levels of inositol result in activation of transcription of several phosphocholine pathway genes and MHO1 and repression of OPT1.