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. 2019 Feb 4;9:1265. doi: 10.1038/s41598-018-37666-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dose-dependent inhibition of tumor cell survival in the presence of CMLD011580. (a–g) Tumor cells of different hematological origins [multiple myeloma (MM1S, JJN3), diffuse large B cell lymphoma (Pfeiffer, Toledo, SC-1), mantle cell lymphoma (Mino), acute myeloid leukemia (AML-2), Burkitt’s lymphoma (Namalwa, Ramos, Raji), T-cell lymphoma (Molt-3) and B-cell lymphoma (RL)] were incubated with the indicated concentrations of CMLD011580 for 48 hrs and cell viability assessed by CellTiter Glo. Results are expressed relative to vehicle controls and are the mean ± SEM of 3 biological replicates. (h) IC₅₀ of (−)-CR-1-31-b and CMDL011580 towards the indicated cells lines. Results are expressed as mean ± SEM of 3 biological replicates.