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. 2019 Feb 4;9:1265. doi: 10.1038/s41598-018-37666-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Biological activity of CMLD011580 in multiple myeloma cells. (a) DEX-dependent synergy with CMLD011580 in JJN3 cells. Cell viability was measured with CellTiter Glo after 48 hours of incubation with different drug combinations. n = 3. (b) Primary human MM cells are sensitive to CMLD011580. Primary tumor cells were exposed ex vivo to 50 nM CMLD011580 or (−)-CR-1-31-b for 72 h, after which point cell viability was determined by flow cytometry as indicated in the Materials and Methods. Presented is the percentage of CD138⁺ cells surviving drug exposure relative to DMSO controls.