Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 4;9:1261. doi: 10.1038/s41598-018-37417-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Model of Ts2631 endolysin binding to peptidoglycan. The Ts2631 endolysin consist two major parts: the structural part with catalytic residues (in red) and flexible N-terminal extension (in blue). Both parts are essential for peptidoglycan (in green) binding (the possible contacts are marked in yellow). While structural part is responsible for lysis of peptidoglycan (coordinated by Zn²⁺ and water molecule and highly conserved catalytic triad), the N-terminal extension can adopt multiple conformations with putative contacts with peptidoglycan far away from the main body of the enzyme (the alternate conformers of the N-terminal extension had been built using Modeller software with DOPE potential)^21,22.