Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 4;9:1292. doi: 10.1038/s41598-018-37785-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Depolarization effects of compounds (DG-5 (a); DG-6 (b); DL-5 (c) and DL-6 (d)) and peptides on S. aureus cytoplasmic membrane. The membrane potential-sensitive fluorescent dye 3,3′-dipropylthiadicarbocyanine Iodide (DiSC3(5)) was used for determining the S. aureus membrane depolarization by measuring fluorescence of the dye release (excitation λ = 622 nm, emission λ = 670 nm). Except for melittin (2 μM), the concentration of control antimicrobial peptides and antimicrobial compounds used is 2X MIC against S. aureus (KCTC 1621) (buforin-2 (16 μM); LL-37 (5 μM); DG-5 (5 μM); DG-6 (5 μM); DL-5 (5 μM), DL-6 (5 μM)). LL-37 and melittin were used as a positive control peptides and buforin-2 was used negative control peptide. The other two triplicate images are presented in Fig. S4 (SI).