Table 2.
Antimicrobial activity.
| Peptide concentration (µg/ml) | |||||||
|---|---|---|---|---|---|---|---|
| Temporin B | Temporin B KKG6A | Temporin B L1FK | |||||
| MHB | TSB | MHB | TSB | MHB | TSB | ||
| Gram-negative | Klebsiella pneumoniae NCTC 13368 | 128 | >128 | 128 | >128 | 32 | 128 |
| Klebsiella pneumoniae M6 | 128 | >128 | 128 | >128 | 32 | 64 | |
| Acinetobacter baumanii AYE | 32 | 64 | 32 | 64 | 8 | 8 | |
| Acinetobacter baumanii ATCC 17978 | 64 | 128 | 32 | 64 | 8 | 16 | |
| Pseudomonas aeruginosa PAO1 | >128 | >128 | >128 | 128 | 128 | 128 | |
| Pseudomonas aeruginosa NCTC 13437 | 128 | >128 | >128 | >128 | 128 | >128 | |
| Escherichia coli NCTC 12923 | 64 | 128 | 16 | 64 | 8 | 64 | |
| Gram-positive | MS Staphylococcus aureus NCTC 6571 | 16 | 16 | 128 | >128 | 4 | 8 |
| EMR Staphylococcus aureus−15 NCTC 13616 | 16 | 64 | >128 | >128 | 16 | 16 | |
| EMR Staphylococcus aureus-16 NCTC 13277 | 32 | 32 | >128 | >128 | 16 | 16 | |
| VS Enterococcus faecalis NCTC 775 | 64 | 128 | >128 | >128 | 32 | 64 | |
| VR Enterococcus faecalis NCTC 12201 | 64 | >128 | >128 | >128 | 64 | 128 | |
| Fungus | Candida albicans NCPF 3179 | 32 | 128 | 64 | 128 | 16 | 64 |
MS – methicillin sensitive; EMR – epidemic methicillin resistant; VS – vancomycin sensitive; VR – vancomycin resistant; MH – Müller-Hinton broth; TSB – tryptic soy broth. Data in bold indicates a four-fold or more increase in MIC or a MIC becoming undetectable according to change in media used.