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. 2019 Jan 18;10(2):48. doi: 10.1038/s41419-018-1281-7

Fig. 5. miR-29c-3p directly targets DNA methyltransferase 3B (DNMT3B) and miR-29c-3p levels were inversely correlated with DNMT3B protein levels.

Fig. 5

a Venn diagram displaying miR-29c-3p computationally predicted to target DNMT3B by four different prediction algorithms: TargetScan, MiRanda, Oncomir, and miRWalk. b miR-29c-3p expression was negatively correlated with DNMT3B expression in hepatocellular carcinoma (HCC) tissues. Spearman's rank test (r = −0.751, p < 0.05). c Diagrams reveal putative miR-29c-3p binding sites and corresponding mutant sites of DNMT3B. d The luciferase activity of each combination was assessed. e DNMT3B mRNA expression in MHCC-97H-pre-miR-29c-3p cells and MHCC-97H -miR-29c-3p inhibitor cells. f Western blotting was performed after transfecting cells with pre-miR-29c-3p or miR-29c-3p inhibitors in MHCC-97H; *p < 0.05, **p < 0.01