Table 1.

miRNA-34a target genes involved in TCR-NF-κB-signaling

Target gene	Aliases	Function	Mutation, gene deletion or silencing phenotype	Refs
TCRA	MD7, TCRD@, TRAC, TRA	Alpha chain of the T cell receptor	TCRA-/- deficient mice: defective thymic Treg selection	25
CD3E	IMD18, T3E, TCRE	Part of T cell receptor-CD3 complex: intracellular signal transduction	CD3E -/-: severe combined immunodeficiency with loss of T cells	26
PLCG1	NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1	Catalyzes inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate.	activating mutations in adult T cell leukemia/lymphoma and angioimmunoblastic T cell lymphoma	49, 32
PIK3CB	P110BETA, PI3K, PI3KBETA, PIK3C1	Catalytic subunit of PIK3	PIK3CB -/- mice: early embryonic lethality	33
TAB2	CHTD2, MAP3K7IP2, TAB-2	IL-1-induced activation of NF-κB	TAB2 -/- mice: early embryonic lethality	50, 35
NFKBIA	IKBA, MAD-3, NFKBI	Inhibitor of NF-κB	NFKBIA -/- mice: severe hematological disorder and hypergranulopoiesis heterozygous mutation Ser 32: impaired NFKB translocation and T cell receptor mediated proliferation	39, 40