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. 2019 Feb 4;9:60. doi: 10.1038/s41398-019-0414-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Pedigree diagram of a fraction of the Northern Sweden pedigree. This demonstrates that all subjects in the study (at bottom, filled = affected, open = unaffected) have a complex pattern of inheritance. All connect to three founder pairs. b Genetic risk scores (GRS) for schizophrenia in pedigree cases (N = 128, narrow definition of illness), pedigree controls (N = 201), and population controls with no lifetime serious mental illness from Northern Sweden (N = 1267). Pedigree cases had significantly greater schizophrenia GRS than pedigree controls and population controls. Pedigree controls and population controls were similar. c As in Fig. 1b but showing GRS for bipolar disorder. GRS for bipolar disorder were slightly greater in pedigree cases than pedigree controls. The training sets for schizophrenia and bipolar disorder were from the PGC after removing Swedish studies. Shown are violin plots with overlaid outlier-style bar plots