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. 2019 Feb 4;9:1281. doi: 10.1038/s41598-019-39018-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of amphiregulin expression on the in vivo tumour formation and angiogenesis in the SK-MEL-28 xenograft model. The SK-MEL-28 cells were transfected with the expression plasmid encoding amphiregulin to establish SK-amphiregulin cells. The SK-amphiregulin and SK-GFP cells, were then subcutaneously transplanted into the immunodeficient mice, followed by the measurement of tumour size (A). (B) Sections of the tumours derived from the SK-GFP (n = 6) and SK-amphiregulin (n = 6) cells were examined by performing immunofluorescence staining with the anti-PECAM-1 antibodies. Scale bars, 200 μm. (C) PECAM-1 positive area represented as the fraction of the total image area. All values are mean ± SE. *p < 0.05; Student’s t-test.