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. 2019 Feb 4;9:1335. doi: 10.1038/s41598-019-38579-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CDC25 inhibitors cause tumor regression and absence of metastasis in a zebrafish K-Ras-dependent tumor model. (A) Fluorescent microscopy images of HCT116 tumor xenografts (shown in red) immediately after implantation (Day 0) in two-days old zebrafish larvae and three days (Day 3) after implantation and treatment with DMSO vehicle (Control), UPD-176 (176), UPD-140 (140) or UPD-738 (738), in five-days old zebrafish larvae. Primary tumors and metastatic sites are shown separately. Metastasized tumor cells are indicated with white arrows. Size-bars in primary tumor images and metastatic site images correspond to 100 µm and 50 µm, respectively. (B,C) Quantifications of relative tumor volumes indicating the primary tumor size at day 3 relative to day 0 (B) or the number of metastasized tumor cells to the bone-marrow-like caudal hematopoietic plexus three days after tumor implantation (C). Results are shown as means (±SEM) of 17, 12, 12 and 17 embryos in the control, UPD-176, UPD-140 and UPD-738 groups, respectively. P-values indicate comparison between control and drug treated groups.