Table 1.
Residues lining the two cavities of CDC25 retrieved by the Site Finder approach.
| Cavity 1 | Cavity 2 | ||||
|---|---|---|---|---|---|
| CDC25A | CDC25B | CDC25C | CDC25A | CDC25B | CDC25C |
| Tyr 387 | Tyr 428 | Tyr 332 | Asp 336 | Glu 377 | His 281 |
| Cys 431 | Cys 473 | Cys 377 | Ile 338 | Ile 379 | Ile 283 |
| Phe 433 | Phe 475 | Phe 379 | Gly 339 | Gly 380 | Gly 284 |
| Ser 434 | Ser 476 | Ser 380 | Tyr 345 | Phe 386 | Cys 290 |
| Glu 436 | Glu 478 | Glu 382 | Asp 356 | Asp 397 | Asp 301 |
| Gly 438 | Gly 480 | Gly 384 | Leu 357 | Leu 398 | Leu 302 |
| Arg 440 | Arg 482 | Arg 386 | Lys 358 | Lys 399 | Lys 303 |
| Met 489 | Met 531 | Met 435 | Cys 442 | Cys 484 | Cys 388 |
| Arg 446 | Arg 488 | Arg 392 | |||
| Arg 450 | Arg 492 | Arg 396 | |||
| Glu 462 | Glu 504 | Glu 408 | |||
| Leu 463 | Met 505 | Leu 409 | |||
The catalytic cysteine in cavity 1 of each phosphatase is shown in italics.