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. 2019 Feb 4;9:1232. doi: 10.1038/s41598-018-37970-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Five-minute segments of MBP and IBI series in a control rat and in a SAD rat at day 1, at day 3 and at 7 months from denervation. MBP variability, with blood pressure sudden reductions, clearly increases immediately after SAD and remains high thereafter. On the other hand, IBI variability, that decreases immediately after SAD, thereafter increases. The increase in IBI variability is sustained by sudden IBI prolongations that coincide with blood pressure reductions.