Figure 3.

Candidate Drugs and Genes from the Druggable Genome Proposed by Multiple Studies. (A) Network representation of candidate drugs discovered by multiple studies and the studies in which they were found. Orange nodes show drugs previously discovered to affect lifespan in animal models (DrugAge), blue nodes show the novel candidates. The identified drugs are linked to the relevant study. (B) Distribution of the number of genes targeted by the identified drugs with respect to the number of studies. The x- and y-axes show the number of studies and genes, respectively. Some genes in the GenAge are not targeted by any novel candidates (0 studies). The pie charts show the percentage of genes in GenAge (human database) for each category. The boxed numbers show the total number of genes in each category.