Table 1.

Physical characteristics of ACY loaded PLGA-NPs.

PLGA-NPs	Particle size (nm) ± SD	Polydispersity ± SD	Zeta-potential (mV) ± SD	% Encapsulation ± SD	% Drug loading ± SD
With polyvinylpyrrolidone (PVP, w/v)
0.5%, (F1)	785.35 ± 35.91	0.484 ± 0.008	−14.51 ± 7.01	58.42 ± 3.58	5.92 ± 1.06
1.0%, (F2)	174.46 ± 15.25	0.297 ± 0.015	−15.82 ± 3.69	60.25 ± 4.92	6.75 ± 1.32
1.5%, (F3)	295.51 ± 17.38	0.222 ± 0.012	−6.04 ± 3.77	63.34 ± 3.85	7.26 ± 1.41
With D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS, w/v)
0.1%, (F4)	293.61 ± 13.78	0.257 ± 0.013	15.28 ± 2.05	32.72 ± 2.98	7.67 ± 1.23
0.3%, (F5)	262.38 ± 11.85	0.255 ± 0.011	15.14 ± 2.81	74.12 ± 6.19	8.65 ± 1.09
0.6%, (F6)	716.15 ± 39.23	0.416 ± 0.023	11.67 ± 1.62	80.15 ± 7.85	5.15 ± 1.38

The values in bold indicate the selected formulation and its parameters.