Table 5.

Pharmacokinetic parameters of ACY in aqueous humor after topical administration of ACY-AqS and PLGA-TPGS-NPs (mean ± SD, n = 3).

Parameters	Values for ACY-AqS	Values for PLGA-TPGS-NPs (F5)
t1/2 (h)	1.908 ± 0.173	3.264 ± 0.067
Tmax (h)	2.0 ± 0.0	6.0 ± 0.0
Cmax (ng mL−1)	7965.024 ± 312.359	8419.081 ± 668.077
AUC0-t (ng mL−1·h)	22627.241 ± 839.556	62816.113 ± 4596.857
AUC0-inf (ng mL−1·h)	23013.076 ± 822.584	63546.783 ± 4727.427
AUC0-t/0-inf	0.9832 ± 0.007	0.9882 ± 0.0013
AUMC0-inf (ngmL−1·h2)	71012.729 ± 12115.95	431247.299 ± 50560.543
MRT0-inf (h)	3.072 ± 0.219	6.771 ± 0.291