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. 2019 Feb 4;9:1183. doi: 10.1038/s41598-018-37661-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Determination of the dominant time constant τ_D of saturated flash response deactivation from Pepperberg plot. (a) LERG-OS response family from WT mouse where the time points of saturated response return to 75% level (T_75%) are determined for the analysis. (b) Pepperberg plot where T_75% values are plotted against the natural logarithm of stimulus strength. Lifetime of active PDE is determined from the linear fit to the data. τ_D for this specific WT retina was 176 ms.