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. 2019 Feb 4;9:1255. doi: 10.1038/s41598-018-38180-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Definition of hydrogen concentration curve measurements. Important concentration curve measurements were as follows. C_max - the maximum plateau concentration where the concentration changes were less than 1% of the difference between baseline and maximum concentrations (i.e., saturation) over 1 min. C_max-adjusted - C_max values adjusted by microsensor signals obtained before staring the inhalation and used as an in vivo calibration. T_sat - the time between initiation of inhalation and beginning of saturation. T₁₀, T₆₃, and T₉₀ - the time taken to reach 10, 63, and 90% of C_max-adjusted, respectively. T_zero - the time required for the hydrogen concentration to reach 3% of C_max-adjusted.