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. 2019 Feb 4;9:1255. doi: 10.1038/s41598-018-38180-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Theoretical models of hydrogen distribution. (A) In gaseous diffusion model, hydrogen concentration would increase more rapidly and would saturate at higher value in the brain than the muscle and other organs based on the distance between the gas supply hood (the face and head) and each organ, although maximum concentration would be lower than the administered level (22.1 μmol/L) due to high diffusion coefficient of hydrogen gas. (B) In blood flow model, hydrogen concentration would increase more gradually in the muscle than other organs due to lower blood flow of muscle, while maximum concentrations would be similar across organs because arterial blood would be saturated at the administered level.