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. 2019 Feb 4;9:65. doi: 10.1038/s41398-019-0399-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Yellow depicts relatively greater changes in activation or functional connectivity. Z-coordinates represented in MNI space. a MID-task activation across all groups. Thresholded statistical map shown (p < 0.00015; FWE corrected for multiple comparisons). b Effect of stimulant drug use on task-related brain activation. Thresholded statistical map showing areas of increased activation in stimulant drug users compared with non-users (p < 0.00015; FWE corrected for multiple comparisons). c Effect of familial risk on putamen functional connectivity to the whole brain. Thresholded statistical map showing areas of altered functional connectivity in familial groups compared with non-familial groups (p < 0.00015; FWE corrected for multiple comparisons)