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. 2019 Jan 18;10(2):53. doi: 10.1038/s41419-018-1279-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Alignment and comparison of aminoacidic sequences of LOX-1 full-length form (NP_002534.1) and LOX-1Δ4 (NP_001166103.1). b Schematic representation of protein products of LOX- 1 and LOX-1Δ4. 5’ UTR, 5’ untranslated region; CY, cytoplasmic domain; TM, transmembrane domain; NECK, neck domain; CLTD, C-terminal lectin type domain; 3’ UTR, 3’ untranslated region. c Western blot analysis of HA-tagged LOX-1 isoforms transfected into MDA-MB-231 cells. d Effects of the overexpression of LOX-1 and LOX-1Δ4 isoforms in breast cancer cell lines. Empty plasmid was used as control (PLA). Values are mean ± SD, and n = 3 (^#p < 0.01 PLA vs LOX-1Δ4; ^§p < 0.05 PLA vs LOX-1)