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. 2019 Jan 18;10(2):53. doi: 10.1038/s41419-018-1279-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a A downregulation of p53 expression was observed in all transfected cells. In LOX-1Δ4-transfected cells we observed a strong increase of Ku70 expression in the cytoplasm. A significant reduction of histone H4 acetylation was observed in LOX-1-transfected cells. b A decrease of p53 level in the nucleus is evident in LOX-1Δ4-transfected cells and a decrease of Ku70 level was observed in the nucleus in LOX-1Δ4transfected cells. A strong decrease in histone H4 acetylation in MDA-MB-231 LOX-1Δ4transfected cells was detected. c In the cytoplasm we observed a light p53 augmentation in LOX-1-transfected cells. Ku70 increases in the nucleus. The overexpression of LOX-1 seems to increase histone H4 acetylation, on the contrary LOX-1Δ4 induce a decrease of acetylation pattern. In all cell lines analyzed, histone H4 was used as internal control. Student’s t tests were used to verify statistically significant (*p < 0.05; **p < 0.01)