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Schematic report of relevant effect of LOX-1 isoforms on proliferation, p53, Ku70, and Ac.H4 modulations in MCF-7, MDA-MB-231 and SK-BR-3 cell lines (N.D: non detectable; =: no modulation observed)
| P53 | KU7O | Ac.H4 | |||||
|---|---|---|---|---|---|---|---|
| Proliferative advantage | Nucleus | Cytoplasm | Nucleus | Cytoplasm | Nucleus | ||
| MCF-7 | LOX-1 | ↑ | − | N.D. | = | + | — |
| LOX-1Δ4 | ↑↑ | − | N.D. | = | ++ | − | |
| MDA-MB-231 | LOX-1 | ↑ | = | = | = | + | + |
| LOX-1Δ4 | ↑↑ | — | + | — | = | — | |
| SK-BR-3 | LOX-1 | ↑↑ | + | + | = | = | ++ |
| LOX-1Δ4 | ↓↓ | + | = | + | = | — | |
