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. 2019 Feb 4;9:1302. doi: 10.1038/s41598-018-37690-5

Figure 2.

Figure 2

The development of chronic kidney disease. (a) Serum carbamide level, (b) serum creatinine level, (c) urine protein level (numeric p-value over the bars refers to a comparison between groups within the same time point), (d) creatinine clearance was calculated from urine volume, urine and serum creatinine concentrations according to a formula (urine creatinine concentration [μM] × urine volume for 24 h [mL])/(serum creatinine concentration [μM] × 24 × 60 min). ¥Urine volume and urine creatinine concentration were measured at week 8 and serum creatinine concentration was determined at week 9. White bars represent the sham-operated group and grey bars represent the chronic kidney disease (CKD) group. Values are means ± SEM, n = 9–10, *p < 0.05 vs. sham within the same time point, #p < 0.05 vs. week −1.