Table 3.
The effect of CKD on blood pressure, body weight and heart weight.
| Parameters | Sham | CKD | p-value |
|---|---|---|---|
| Body weight (g) (week −1) | 283 ± 6 | 284 ± 12 | 0.954 |
| Body weight (g) (week 9) | 431 ± 13 | 425 ± 13 | 0.734 |
| Heart weight (mg) | 1193 ± 41 | 1318 ± 55* | 0.031 |
| Heart weight/body weight (mg/g) | 2.77 ± 0.06 | 3.11 ± 0.13* | 0.029 |
| Systolic blood pressure (mmHg) | 138 ± 3 | 146 ± 5 | 0.145 |
| Diastolic blood pressure (mmHg) | 117 ± 2 | 122 ± 4 | 0.240 |
| Mean arterial blood pressure (mmHg) | 127 ± 2 | 134 ± 4 | 0.148 |
Values are mean ± SEM, n = 9–10, *p < 0.05 vs. control, unpaired t-test. CKD: chronic kidney disease. Blood pressure was measured at week 8 in a subgroup of animals. Heart weight was measured at week 9.