Table 5.
The effect of CKD on molecular markers of the calcineurin/NFAT pathway at the mRNA level.
| Gene name | Gene symbol | log2 change | SD log2 change | p-value | Fold change |
|---|---|---|---|---|---|
| Protein phosphatase 3 catalytic subunit alpha | Ppp3ca | 0.14 | 0.21 | 0.000 | 1.10 |
| Protein phosphatase 3 catalytic subunit beta | Ppp3cb | 0.01 | 0.38 | 0.896 | 1.01 |
| Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 4 | Nfatc4 | −0.05 | 0.97 | 0.775 | −1.03 |
| Muscle Atrophy F-Box Protein (atrogin-1) | Fbx32 | −0.92 | 1.21 | 0.001 | −1.89 |
| Myocyte-Enriched Calcineurin-Interacting Protein 1 (MCIP1.4) | Rcan1 | −0.12 | 1.81 | 0.781 | −1.09 |
Gene expression ratios (CKD vs. control). Fold change of <−1.75 or >1.75 (repression or overexpression, respectively) and a p-value of <0.05 were considered as a significant change, n = 5–6, unpaired t-test.