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. 2019 Feb 4;9:1263. doi: 10.1038/s41598-018-37419-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Astrocytes and blood vessels were labeled with SR101 and FITC-dextran. Astrocytes were labeled with SR101 (red) and blood vessels were labeled with FITC-dextran (4 kDa, green). Astrocytic endfeet covering blood vessels were laser ablated. (A) The ablated endfoot disappeared 60 min after the laser irradiation (arrowhead in Ab), and the blood vessel was re-covered by an astrocytic endfoot 360 min later (arrow in Ac). Dotted line in Aa indicates the location of laser ablation. (B) An astrocytic endfoot disappeared (arrowhead in Bb) one min after laser ablation (dotted line in Ba). Leakage of FITC-dextran was not observed. Scale bars, 10 µm. Images were constructed by maximum intensity z-projections of 60–70 (A) and 25–35 µm (B) depth from the brain surface.