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. 2019 Feb 4;10(2):99. doi: 10.1038/s41419-019-1371-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Depletion of CHD1L expression enhances the sensitivity of xenograft tumors to cisplatin. a A549/DDP cells transfected with CHD1L-shRNA-1 or CHD1L-shRNA-2 were treated with cisplatin at the indicated concentration for 14 days. Colonies were stained with crystal violet (Left). The number of colonies were taken from three independent experiments (Right). b CHD1L knockdown reverses cisplatin resistance of cisplatin-resistant cells in xenograft tumors implanted onto adult female nude mice. A549/DDP cells transfected with CHD1L-shRNA-1 or CHD1L-shRNA-2 were subcutaneously injected to generate xenograft tumors in nude mice; cisplatin treatment was performed as described in Materials and Methods. Normal saline (n.s.) was used as a treatment control. Images of xenograft tumors harvested at the end of the experiment. c Growth curves of tumor xenografts. d The weights of tumors are presented as a Cleveland dot plot, and the average ±S.D is included (n=6/group; **P< 0.01; ***P <0.001; NS, no significance)