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. 2019 Feb 4;10(2):99. doi: 10.1038/s41419-019-1371-1

Fig. 5.

Fig. 5

Depletion of CHD1L expression enhances the sensitivity of xenograft tumors to cisplatin. a A549/DDP cells transfected with CHD1L-shRNA-1 or CHD1L-shRNA-2 were treated with cisplatin at the indicated concentration for 14 days. Colonies were stained with crystal violet (Left). The number of colonies were taken from three independent experiments (Right). b CHD1L knockdown reverses cisplatin resistance of cisplatin-resistant cells in xenograft tumors implanted onto adult female nude mice. A549/DDP cells transfected with CHD1L-shRNA-1 or CHD1L-shRNA-2 were subcutaneously injected to generate xenograft tumors in nude mice; cisplatin treatment was performed as described in Materials and Methods. Normal saline (n.s.) was used as a treatment control. Images of xenograft tumors harvested at the end of the experiment. c Growth curves of tumor xenografts. d The weights of tumors are presented as a Cleveland dot plot, and the average ±S.D is included (n=6/group; **P< 0.01; ***P <0.001; NS, no significance)