Table 1.
Baseline characteristics of preterm infants stratified by presence of moderate-to-severe cerebellar injury on conventional MRI.
| Demographics | All infants with valid H1-MRS (n = 53) | Infants with no/mild cerebellar injury (n = 39) | Infants with moderate-to-severe structural cerebellar injury (n = 14) | P value |
|---|---|---|---|---|
| Birth Weight (in kg), median (IQR) | 0.90 (0.65–1.17) | 1.08 (0.73–1.28) | 0.65 (0.58–0.87) | 0.004 |
| Gestational age (in weeks), median (IQR) | 27.0 (25.0–29.0) | 28.0 (25.9–29.6) | 24.3 (23.1–26.1) | <0.001 |
| WOL at MRI (in weeks), median (IQR) | 5.7 (4.2–8.1) | 5.4 (3.9–7.9) | 7.8 94.9–9.2) | 0.10 |
| PMA at MRI (in weeks), median (IQR) | 33.0 (31.6–35.2) | 33.7 (31.6–35.9) | 32.2 (30.7–33.3) | 0.059 |
| Female gender (%) | 30 (56.6%) | 22 (56.4%) | 8 (57.1%) | 0.8 |
| Apgar at 5 min | 10 (19.3%) | 8 (6–9) | 6 (4–8) | 0.02 |
| Gravida | 3 (1–5) | 2 (1–4) | 3 (2–5) | 0.2 |
| Parity | 1 (1–3) | 2 (1–3) | 1 (0–1) | 0.035 |
| Single gestation | 41 (87.3%) | 31 (79.5%) | 10 (71.4%) | 0.7 |
| Child Race (White) | 29 (54.7%) | 23 (59.0%) | 6 (42.9%) | 0.4 |
| Chorioamnionitis | 12 (29.3%) | 10 (25.6%) | 2 (14.3%) | 0.5 |
| C-sec delivery | 36 (67.9%) | 30 (76.9%) | 6 (42.8%) | 0.042 |
| Pregnancy induced hypertension | 12 (22.6%) | 10 (25.6%) | 2 (14.3%) | 0.5 |
| Maternal diabetes | 2 (3.8%) | 1 (2.6%) | 1 (7.1%) | 0.5 |
| Complications of prematurity | ||||
| BPD (moderate-to-severe) | 27 (51.9%) | 16 (41.1%) | 11 (78.6%) | 0.043 |
| PDA ligation | 10 (18.9%) | 5 (12.8%) | 5 (35.7%) | 0.1 |
| Definite NEC ≥ stage2 | 15 (28.3%) | 9 (23.1%) | 6 (40.0%) | 0.2 |
| NEC surgery | 9 (17.0%) | 5 (12.8%) | 4 (28.6%) | 0.2 |
| Culture positive infection | 10 (18.9%) | 7 (17.9%) | 3 (21.4%) | 1 |
| ROP ≥ stage 2 | 18 (34.6%) | 10 (26.3%) | 8 (57.1%) | 0.052 |
| IVH ≥ grade 3 | 14 (26.5%) | 7 (17.9%) | 7 (50.0%) | 0.033 |
| Brain injury (moderate-to-severe) | 14 (26.5%) | 13 (33.3%) | 1 (7.1%) | <0.001 |