Table 3.
Relationship of cerebellar metabolite concentrations and ratios with cerebellar injury on TEA MRI.
| Metabolite Concentration or Ratio | No of infants with Cerebellar injury/Valid H1-MRS (n/N) | Infants with no/mild cerebellar injury Median (IQR) (in i.u.) | Infants with moderate-to-severe structural cerebellar injury Median (IQR) (in i.u.) | Mann-Whitney Test P value |
|---|---|---|---|---|
| NAA | 11/44 | 3.44 (2.88–4.51) | 2.21 (1.87–3.04) | <0.001 |
| Cr | 14/52 | 4.22 (3.50–6.37) | 3.0 (2.22–3.5) | <0.001 |
| Cho | 14/53 | 3.4 (3.02–4.38) | 2.46 (1.87–2.97) | <0.001 |
| Ins | 3/14 | 16.41 (11.62–17.5) | 12.71 (11.97–20.37) | 0.9 |
| Lac40 | 6/21 | 1.72 (1.40–2.35) | 1.51 (1.05–1.72) | 0.09 |
| NAA/Cr | 11/44 | 0.78 (0.65–0.91) | 0.76 (0.71–0.83) | 1 |
| NAA/Cho | 11/44 | 1.04 (0.95–1.14) | 0.88 (0.77–1.21) | 0.3 |
| Cho/Cr | 14/53 | 0.78 (0.65–0.91) | 0.85 (0.70–0.94) | 0.4 |