Figure S6. Clinical features of the affected father of the proband in family 2.

He presented with typical LK phenotypes, including generalized ichthyosis (A, D) and well-demarcated erythematous plaques (D). Notably, he exhibited multiple, clinically reverted skin spots on his extremities (A–E). Arrows, arrowheads, and asterisks indicate representative spots. These clinical images were taken when he was 57.