Table 2.

Cox Proportional Hazards Regression Analysis of Predictors Associated With 14-Day Mortality of Patients With Carbapenem-Resistant Klebsiella pneumoniae and Escherichia coli Bloodstream Infections^a

Variables	Univariate Analysis		Multivariable Analysis
	HR (95% CI)	P	HR (95% CI)	P
Chronic respiratory failure with mechanical ventilator	2.14 (0.87–5.24)	.096
Malignancy	2.29 (0.94–5.62)	.069
Charlson Comorbidity Index	1.11 (0.96–1.29)	.147	1.21 (1.03–1.42)	.022
Surgical drain	1.93 (0.74–5.02)	.180
Septic shock	2.08 (0.80–5.42)	.134
APACHE II score	1.07 (1.01–1.13)	.024
Colistin monotherapy	4.05 (1.65–9.96)	.002	5.57 (2.13–14.61)	<.001
Other monotherapy	0.25 (0.07–0.86)	.028

Abbreviations: APACHE, Acute Physiology and Chronic Health Evaluation; CI, confidence interval; HR, hazard ratio; ICU, intensive care unit.

^aAll biologically relevant variables with P < .20 in the univariate cox proportional regression analysis were included in the multivariate analysis.