Table 4.

Longitudinal changes in antihyperglycemic treatment intensity and insulin use by islet autoantibody status over six years, among participants not using insulin at baseline

	Autoantibody Negative	Any Autoantibody Positive	P-valuea
All participants	n=163	n=9
Increased treatment intensity	91 (55.8)	9 (100)	0.011
Initiated insulin	27 (16.6)	2 (22.2)	0.649
DSE arm	n=78	n=4
Increased treatment intensity	55 (70.5)	4 (100)	0.573
Initiated insulin	16 (20.5)	2 (50)	0.208
ILI arm	n=85	n=5
Increased treatment intensity	36 (42.4)	5 (100)	0.017
Initiated insulin	11 (12.9)	0 (0)	1.000

Data expressed as n (%). Increased treatment intensity defined as increasing the number of glucose lowering medications or starting insulin.

Abbreviations: DSE, Diabetes Support & Education; ILI, Intensive Lifestyle Intervention.

^aFisher’s exact test.