. 2019 Jan 29;10:6. doi: 10.3389/fimmu.2019.00006

Table 2.

Correlation analysis between LAYN and relate genes and markers of immune cells in TIMER.

Description	Gene markers	COAD				STAD				LUSC
		None		Purity		None		Purity		None		Purity
		Cor	P	Cor	P	Cor	P	Cor	P	Cor	P	Cor	P
CD8+ T cell	CD8A	0.359	^***	0.252	^***	0.374	^***	0.34	^***	−0.04	0.368	−0.062	0.174
	CD8B	0.252	^***	0.214	^***	0.242	^***	0.224	^***	−0.005	0.913	−0.022	0.627
T cell (general)	CD3D	0.335	^***	0.22	^***	0.324	^***	0.281	^***	0.000	0.998	−0.022	0.639
	CD3E	0.397	^***	0.273	^***	0.352	^***	0.314	^***	−0.023	0.608	−0.054	0.241
	CD2	0.386	^***	0.265	^***	0.386	^***	0.353	^***	0.001	0.974	−0.028	0.544
B cell	CD19	0.253	^***	0.118	0.017	0.322	^***	0.305	^***	0.016	0.722	−0.006	0.896
	CD79A	0.334	^***	0.183	^**	0.345	^***	0.307	^***	0.046	0.306	0.026	0.572
Monocyte	CD86	0.697	^***	0.646	^***	0.468	^***	0.441	^***	0.068	0.127	0.034	0.464
	CD115 (CSF1R)	0.669	^***	0.609	^***	0.552	^***	0.53	^***	0.072	0.105	0.045	0.330
TAM	CCL2	0.724	^***	0.684	^***	0.521	^***	0.498	^***	0.087	0.051	0.068	0.140
	CD68	0.512	^***	0.453	^***	0.229	^***	0.207	^***	0.119	^*	0.088	0.053
	IL10	0.553	^***	0.523	^***	0.445	^***	0.436	^***	0.08	0.074	0.066	0.147
M1 Macrophage	INOS (NOS2)	−0.198	^***	−0.266	^***	−0.032	0.513	−0.04	0.397	0.125	^*	0.123	^*
	IRF5	0.264	^***	0.287	^***	0.191	^***	0.169	^**	0.142	^*	0.138	^*
	COX2(PTGS2)	0.286	^***	0.222	^***	0.253	^***	0.253	^***	0.004	0.932	−0.008	0.863
M2 Macrophage	CD163	0.676	^***	0.625	^***	0.488	^***	0.467	^***	0.061	0.173	0.035	0.440
	VSIG4	0.772	^***	0.681	^***	0.524	^***	0.513	^***	.087	0.521	0.063	0.166
	MS4A4A	0.689	^***	0.649	^***	0.556	^***	0.538	^***	0.155	0.010	0.097	0.034
Neutrophils	CD66b (CEACAM8)	−0.019	0.69	0.024	0.633	−0.019	0.694	−0.01	0.868	0.049	0.271	0.038	0.402
	CD11b (ITGAM)	0.719	^***	0.664	^***	0.489	^***	0.481	^***	0.046	0.307	0.008	0.866
	CCR7	0.39	^***	0.262	^***	0.425	^***	0.393	^***	0.027	0.550	0.002	0.971
Natural killer cell	KIR2DL1	0.204	^***	0.152	^*	0.202	^***	0.187	^**	−0.135	^*	−0.148	^*
	KIR2DL3	0.163	^**	0.113	0.022	0.146	^*	0.117	0.023	−0.154	^**	−0.17	^**
	KIR2DL4	0.161	^**	0.075	0.129	0.015	0.756	−0.03	0.614	−0.079	0.078	−0.105	0.022
	KIR3DL1	0.2	^***	0.123	0.013	0.194	^***	0.169	^**	−0.047	0.291	−0.069	0.131
	KIR3DL2	0.188	^***	0.096	0.052	0.199	^***	0.166	^*	−0.095	0.033	−0.115	0.012
	KIR3DL3	0.01	0.83	−0.011	0.833	−0.087	0.078	−0.08	0.118	−0.114	0.010	−0.13	^*
	KIR2DS4	0.163	^**	0.129	^*	0.092	0.061	0.074	0.151	−0.017	0.701	−0.02	0.659
Dendritic cell	HLA-DPB1	0.596	^***	0.52	^***	0.377	^***	0.329	^***	0.043	0.338	0.023	0.622
	HLA-DQB1	0.365	^***	0.279	^***	0.207	^***	0.151	^*	0.069	0.120	0.064	0.162
	HLA-DRA	0.532	^***	0.454	^***	0.284	^***	0.236	^***	0.037	0.414	0.013	0.780
	HLA-DPA1	0.562	^***	0.487	^***	0.325	^***	0.277	^***	0.037	0.413	0.012	0.786
	BDCA-1(CD1C)	0.458	^***	0.38	^***	0.448	^***	0.432	^***	0.139	^*	0.134	^*
	BDCA-4(NRP1)	0.72	^***	0.665	^***	0.688	^***	0.681	^***	0.035	0.429	0.015	0.748
	CD11c (ITGAX)	0.672	^***	0.606	^***	0.439	^***	0.411	^***	0.02	0.651	−0.015	0.736
Th1	T-bet (TBX21)	0.381	^***	0.283	^***	0.339	^***	0.315	^***	−0.08	0.718	−0.111	0.016
	STAT4	0.389	^***	0.305	^***	0.426	^***	0.403	^***	0.073	0.105	0.054	0.237
	STAT1	0.351	^***	0.292	^***	0.041	0.41	0.012	0.811	−0.062	0.163	−0.088	0.055
	IFN-γ (IFNG)	0.218	^***	0.17	^**	0.081	0.1	0.005	0.334	−0.099	0.027	−0.117	0.011
	TNF-α (TNF)	0.353	^***	0.298	^***	0.119	0.016	0.073	0.156	0.091	0.042	0.06	0.192
Th2	GATA3	0.471	^***	0.389	^***	0.419	^***	0.403	^***	−0.08	0.074	−0.108	0.018
	STAT6	−0.103	0.03	−0.102	0.040	0.096	0.051	0.089	0.083	0.018	0.680	0.002	0.666
	STAT5A	0.211	^***	0.179	^**	0.404	^***	0.388	^***	0.006	0.899	−0.023	0.623
	IL13	0.302	^***	0.217	^***	0.136	^*	0.149	^*	−0.017	0.705	−0.039	0.400
Tfh	BCL6	0.498	^***	0.436	^***	0.507	^***	0.479	^***	0.055	0.219	0.063	0.169
	IL21	0.198	^***	0.155	^*	0.142	^*	0.129	0.012	−0.084	0.059	−0.102	0.025
Th17	STAT3	0.192	^***	0.122	0.014	0.409	^***	0.393	^***	0.043	0.339	0.033	0.474
	IL17A	−0.191	^***	−0.223	^***	−0.201	^***	−0.21	^***	−0.105	0.019	−0.109	0.018
Treg	FOXP3	0.553	^***	0.46	^***	0.319	^***	0.282	^***	0.038	0.395	0.007	0.878
	CCR8	0.531	^***	0.467	^***	0.427	^***	0.416	^***	0.091	0.041	0.059	0.196
	STAT5B	0.179	^**	0.199	^***	0.537	^***	0.534	^***	0.018	0.683	0.024	0.597
	TGFβ (TGFB1)	0.689	^***	0.623	^***	0.592	^***	0.572	^***	0.116	^*	0.102	0.025
T cell exhaustion	PD-1 (PDCD1)	0.354	^***	0.241	^***	0.24	^***	0.203	^***	−0.079	0.077	−0.108	0.018
	CTLA4	0.444	^***	0.349	^***	0.203	^***	0.167	^*	0.008	0.850	−0.025	0.586
	LAG3	0.348	^***	0.245	^***	0.236	^***	0.202	^***	−0.1	0.245	−0.133	^*
	TIM-3 (HAVCR2)	0.713	^***	0.681	^***	0.457	^***	0.436	^***	0.083	0.062	0.063	0.172
	GZMB	0.128	^*	0.112	0.024	0.163	^**	0.111	0.031	−0.046	0.308	−0.079	0.086

CODA, colon adenocarcinoma; STAD, stomach adenocarcinoma; LUSC, lung squamous cell carcinoma; TAM, tumor-associated macrophage; Th, T helper cell; Tfh, Follicular helper T cell; Treg, regulatory T cell; Cor, R value of Spearman's correlation; None, correlation without adjustment. Purity, correlation adjusted by purity.

P < 0.01;

^**

P < 0.001;

^***

P < 0.0001.