Table 3.
Correlation analysis between LAYN and relate genes and markers of monocyte and macrophages in GEPIA.
| Description | Gene markers | CODA | STAD | LUSC | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tumor | Normal | Tumor | Normal | Tumor | Normal | ||||||||
| R | P | R | P | R | P | R | P | R | P | R | P | ||
| Monocyte | CD86 | 0.75 | *** | 0.074 | 0.65 | 0.5 | *** | −0.12 | 0.48 | 0.083 | 0.067 | 0.19 | 0.18 |
| CD115 (CSF1R) | 0.76 | *** | −0.045 | 0.78 | 0.61 | *** | 0.15 | 0.39 | 0.11 | 0.02 | 0.094 | 0.52 | |
| TAM | CCL2 | 0.8 | *** | 0.53 | ** | 0.55 | *** | 0.62 | *** | 0.11 | 0.014 | −0.19 | 0.19 |
| CD68 | 0.6 | *** | −0.1 | 0.51 | 0.3 | *** | −0.49 | * | 0.14 | * | −0.15 | 0.31 | |
| IL10 | 0.65 | *** | 0.19 | 0.24 | 0.49 | *** | 0.14 | 0.42 | 0.086 | 0.058 | 0.029 | 0.84 | |
| M1 Macrophage | INOS (NOS2) | −0.1 | 0.086 | −0.031 | 0.85 | −0.002 | 0.98 | 0.1 | 0.56 | 0.15 | ** | 0.17 | 0.22 |
| IRF5 | 0.33 | *** | −0.19 | 0.23 | 0.27 | *** | −0.33 | 0.049 | 0.18 | *** | −0.02 | 0.91 | |
| COX2 (PTGS2) | 0.37 | *** | 0.57 | *** | 0.3 | *** | 0.85 | *** | 0.0087 | 0.85 | −0.14 | 0.33 | |
| M2 Macrophage | CD163 | 0.75 | *** | 0.21 | *** | 0.55 | *** | 0.59 | ** | 0.066 | 0.14 | −0.28 | 0.053 |
| VSIG4 | 0.78 | *** | 0.32 | 0.045 | 0.58 | *** | 0.46 | * | 0.088 | 0.053 | −0.04 | 0.77 | |
| MS4A4A | 0.75 | *** | 0.23 | 0.14 | 0.6 | *** | 0.58 | ** | 0.11 | 0.013 | 0.038 | 0.79 | |
CODA, colon adenocarcinoma; STAD, stomach adenocarcinoma; LUSC, lung squamous cell carcinoma. TAM, Tumor-associated macrophages.
Tumor, correlation analysis in tumor tissue of TCGA. Normal, correlation analysis in normal tissue of TCGA.
P < 0.01;
P < 0.001;
P < 0.0001.