Table 4. . Inhibitory activity of acyclic (butenyl) alpha-carboxynucleoside phosphonates against viral and cellular DNA polymerases.
| Enzyme source | IC50† DNA polymerase (μM) | |||
|---|---|---|---|---|
| Butenyl T-α-CNP | Butenyl C-α-CNP | Butenyl A-α-CNP | Butenyl G-α-CNP | |
| HSV-1 DNA pol | 3.7 | 12 | 2.7 | 2.1 |
| HCMV DNA pol | 2.1 | 16 | 5.5 | 3.6 |
| VZV DNA pol | 2.2 | 2.9 | 3.3 | 2.9 |
| DNA pol α | 14 | 414 | ≥500 | 365 |
| DNA pol β | >500 | >500 | 454 | >500 |
†Data taken from [32].
α-CNP: Alpha-carboxynucleoside phosphonate; HCMV: Human cytomegalovirus; HSV-1: Herpes simplex virus type 1; IC50: 50% inhibitory concentration; RT: Reverse transcriptase; VZV: Varicella-zoster virus.