Table 4:

Background, Presentation, Management and Complications of 9 Children with Invasive Haemophilus influenzae type a (Hia) Disease in Alaska who Died or Had Ongoing Complications after 1 Year, 2002–2014

Case	Age in months, sex	Underlying condition	Presentation (duration)	Site	Complications, Other Management	Sequelae by 1 year
1	6, male	Hypohydratic ectodermal dysplasia	Unknown	Not localized (Hia from lung tissue on autopsy*)	Cardiac arrest in community (witnessed by village health aide)	Died
2	4, female	No	Fever and seizure (1 day)	Meningitis (Hia in CSF on autopsy)	Cardiac arrest in flight (managed by evacuation team)	Died
3	8, male	No	Fever and seizure (5 days)	Not localized (Hia on blood culture)	Intensive care, ventilated	Died (cardiac arrest in intensive care)
4	5, male	No	Fever, nausea, irritability (1 day)	Meningitis (Hia in CSF)	Intensive care, ventilated	Died (died 4 days after discharge)†
5	5, male	Born at 36 weeks	Cough, fever (1 week)	Meningitis (Hia in blood, CSF)	Transfer to specialist center, Burr hole for frontoparietal empyema	Speech delay
6	9, male	No	Seizure after prodrome (5 days)	Meningitis (Hia in blood, CSF)	Communicating hydrocephalus, ventriculo-peritoneal shunt	Hearing loss, possible ongoing developmental delay
7	8, male	Recurrent pneumonia	Cough, fever (1 day)	Pneumonia (Hia in pleural fluid*)	Middle cerebral artery stroke	Hemiparesis
8	6, male	No	Lethargy, bulging fontanelle after prodrome (3 days)	Meningitis (Hia in blood, CSF)	Middle cerebral artery stroke	Hemiparesis, hearing loss
9	6, male	Born at 35 weeks	Lethargic following prodrome	Meningitis‡ (Hia in blood)	Middle cerebral artery stroke	Hemiparesis, hearing loss, speech delay

^*PCR positive only

^†Chief Medical Examiner attributed this death to Hia

^‡Radiological evidence of meningitis