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. 2018 Dec 20;28(2):145–156. doi: 10.1177/0963689718819443

Fig. 1.

Fig. 1.

(A) In 2 h MCA occlusion groups, body temperatures (n=8 per group) were measured in a time-dependent manner. ANOVA analyses indicated that C+P significantly (##P<0.01) reduced body temperature as early as within 5 min and lasting up to 12 h after stroke onset. (B) Infarct volume reduction by drug-induced hypothermia from C+P. TTC histology demonstrating infarct volume reduction in the penumbra region of ischemic territory supplied by MCA with C+P± temperature control after 2 h MCA occlusion. (C) Quantification of infarct volume reduction by C+P. Treatments without temperature control were allowed to reach drug-induced hypothermia as indicated in Fig. 1A and demonstrated slightly greater but not significant infarct volume reduction than subjects maintained at 37°C.